Assay Detail
Binding
CHEMBL996509
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Inhibition of PDE in Sprague-Dawley rat epididymal adipose tissue assessed as [14C]adenosine recovery by liquid scintillation counting
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Adipose tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.34 | 6.57 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | — | 2 | 6.57 |
| CHEMBL378188 | BILOBETIN | — | 2 | 6.44 |
| CHEMBL255493 | SEQUOIAFLAVONE | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL378188 | BILOBETIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL255493 | SEQUOIAFLAVONE | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL378188 | BILOBETIN | Inhibition | = | 84.0 | % | - |
| CHEMBL63354 | AMENTOFLAVONE | Inhibition | = | 85.0 | % | - |