Assay Detail
Binding
CHEMBL996768
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Binding affinity to glucagon receptor in pig liver membrane by membrane filter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.31 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492813 | — | — | 1 | 5.48 |
| CHEMBL471580 | — | — | 1 | 5.40 |
| CHEMBL501628 | — | — | 1 | 5.28 |
| CHEMBL519776 | — | — | 1 | 5.24 |
| CHEMBL470729 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492813 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL471580 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL501628 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL519776 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL470729 | — | IC50 | = | 7000.0 | nM | 5.16 |