Assay Detail
Binding
CHEMBL996769
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Binding affinity to glucagon receptor in dog liver membrane by membrane filter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.04 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471580 | — | — | 1 | 7.17 |
| CHEMBL519776 | — | — | 1 | 7.11 |
| CHEMBL492813 | — | — | 1 | 7.09 |
| CHEMBL501628 | — | — | 1 | 7.02 |
| CHEMBL470729 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471580 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL519776 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL492813 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL501628 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL470729 | — | IC50 | = | 155.0 | nM | 6.81 |