Assay Detail
Binding
CHEMBL996770
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Binding affinity to glucagon receptor in monkey liver membrane by membrane filter assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca mulatta |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.30 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451288 | — | — | 1 | 8.52 |
| CHEMBL471580 | — | — | 1 | 7.29 |
| CHEMBL492813 | — | — | 1 | 7.26 |
| CHEMBL519776 | — | — | 1 | 7.22 |
| CHEMBL455323 | — | — | 1 | 7.21 |
| CHEMBL501628 | — | — | 1 | 7.14 |
| CHEMBL492605 | — | — | 1 | 7.09 |
| CHEMBL446821 | — | — | 1 | 7.03 |
| CHEMBL470729 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451288 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL471580 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL492813 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL519776 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL455323 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL501628 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL492605 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL446821 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL470729 | — | IC50 | = | 114.0 | nM | 6.94 |