Assay Detail
Functional
CHEMBL996799
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Antiviral activity against HCV subtype 1a in Huh7 cells assessed as reduction of viral RNA replication
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.14 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 5.85 |
| CHEMBL521602 | — | — | 1 | 5.37 |
| CHEMBL522790 | — | — | 1 | 5.25 |
| CHEMBL490623 | — | — | 1 | 5.19 |
| CHEMBL506980 | — | — | 1 | 5.05 |
| CHEMBL490625 | — | — | 1 | 4.99 |
| CHEMBL490624 | — | — | 1 | 4.96 |
| CHEMBL485293 | — | — | 1 | 4.89 |
| CHEMBL490830 | — | — | 1 | 4.72 |
| CHEMBL509779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL393857 | 4'-AZIDOCYTIDINE | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL521602 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL522790 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL490623 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL506980 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL490625 | — | EC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL490624 | — | EC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL485293 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL490830 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL509779 | — | EC50 | > | 100000.0 | nM | - |