Assay Detail
Binding
CHEMBL996963
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Inhibition of c-Src
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.85 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520904 | — | — | 1 | 5.60 |
| CHEMBL508515 | — | — | 1 | 5.25 |
| CHEMBL462170 | — | — | 1 | 4.89 |
| CHEMBL453347 | — | — | 1 | 4.77 |
| CHEMBL488899 | — | — | 1 | 4.57 |
| CHEMBL519891 | — | — | 1 | 4.51 |
| CHEMBL510668 | — | — | 1 | 4.34 |
| CHEMBL379975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520904 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL508515 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL462170 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL453347 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL488899 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL519891 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL510668 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL379975 | — | IC50 | > | 50000.0 | nM | - |