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Assay Detail

CHEMBL997003

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Helicobacter pylori urease
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Helicobacter pylori
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Urease (CHEMBL5325)
Type SINGLE PROTEIN
Organism Helicobacter pylori

Publication

Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases.
Vassiliou S, Grabowiecka A, Kosikowska P, Yiotakis A, Kafarski P, Berlicki Ł.
J Med Chem (2008) 51 : 5736 -5744
PubMed 18717581 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.10 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL462481 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL462481 IC50 = 790.0 nM 6.10