Assay Detail
Binding
CHEMBL997061
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Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.77 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 10.00 |
| CHEMBL503885 | — | — | 1 | 8.30 |
| CHEMBL525042 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL503885 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL525042 | — | IC50 | = | 10.0 | nM | 8.00 |