Assay Detail
Functional
CHEMBL997127
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Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.88 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258402 | — | — | 1 | 7.70 |
| CHEMBL336434 | — | — | 1 | 5.66 |
| CHEMBL65606 | TMPYP4 | — | 1 | 5.21 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258402 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL336434 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL65606 | TMPYP4 | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL941 | IMATINIB | IC50 | = | 11500.0 | nM | 4.94 |