Assay Detail
Binding
CHEMBL997203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.31 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467896 | — | — | 1 | 8.02 |
| CHEMBL467475 | — | — | 1 | 7.75 |
| CHEMBL508336 | — | — | 1 | 7.25 |
| CHEMBL466651 | — | — | 1 | 6.70 |
| CHEMBL466047 | — | — | 1 | 6.70 |
| CHEMBL512063 | — | — | 1 | 6.52 |
| CHEMBL381689 | SR-144528 | — | 1 | 6.36 |
| CHEMBL466623 | — | — | 1 | 6.25 |
| CHEMBL446993 | — | — | 1 | 6.25 |
| CHEMBL371214 | — | — | 1 | 6.17 |
| CHEMBL511253 | — | — | 1 | 6.02 |
| CHEMBL466223 | — | — | 1 | 6.00 |
| CHEMBL467681 | — | — | 1 | 5.82 |
| CHEMBL467476 | — | — | 1 | 5.80 |
| CHEMBL467680 | — | — | 1 | 5.28 |
| CHEMBL513298 | — | — | 1 | 5.25 |
| CHEMBL466429 | — | — | 1 | 5.16 |
| CHEMBL466428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467896 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL467475 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL508336 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL466651 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL466047 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL512063 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL381689 | SR-144528 | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL466623 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL446993 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL371214 | — | Ki | = | 677.0 | nM | 6.17 |
| CHEMBL511253 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL466223 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL467681 | — | Ki | = | 1519.0 | nM | 5.82 |
| CHEMBL467476 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL467680 | — | Ki | = | 5255.0 | nM | 5.28 |
| CHEMBL513298 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL466429 | — | Ki | = | 6947.0 | nM | 5.16 |
| CHEMBL466428 | — | Ki | - | — | - |