Assay Detail
Binding
CHEMBL997251
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Inhibition of human 11beta-HSD1 in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.44 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495841 | — | — | 1 | 8.30 |
| CHEMBL495840 | — | — | 1 | 8.30 |
| CHEMBL489857 | — | — | 1 | 8.00 |
| CHEMBL496082 | — | — | 1 | 7.40 |
| CHEMBL526098 | — | — | 1 | 7.40 |
| CHEMBL497105 | — | — | 1 | 7.30 |
| CHEMBL495842 | — | — | 1 | 6.74 |
| CHEMBL523284 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495841 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL495840 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL489857 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL496082 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL526098 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL497105 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL495842 | — | EC50 | = | 184.0 | nM | 6.74 |
| CHEMBL523284 | — | EC50 | = | 846.0 | nM | 6.07 |