Assay Detail
Binding
CHEMBL997267
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Inhibition of pig pancreatic group1 sPLA2 at 10 uM by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.70 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480874 | CACOSPONGIONOLIDE E | — | 1 | 5.28 |
| CHEMBL480681 | CACOSPONGIONOLIDE | — | 1 | 4.84 |
| CHEMBL463914 | MANOALIDE | — | 1 | 4.49 |
| CHEMBL111739 | CACOSPONGIONOLIDE B | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480874 | CACOSPONGIONOLIDE E | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL480681 | CACOSPONGIONOLIDE | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL463914 | MANOALIDE | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL111739 | CACOSPONGIONOLIDE B | IC50 | = | 64200.0 | nM | 4.19 |