Assay Detail
Binding
CHEMBL997270
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human synovial group2 sPLA2 by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipase A2, membrane associated (CHEMBL3474) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.54 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480874 | CACOSPONGIONOLIDE E | — | 1 | 5.85 |
| CHEMBL480681 | CACOSPONGIONOLIDE | — | 1 | 5.52 |
| CHEMBL463914 | MANOALIDE | — | 1 | 5.41 |
| CHEMBL111739 | CACOSPONGIONOLIDE B | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480874 | CACOSPONGIONOLIDE E | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL480681 | CACOSPONGIONOLIDE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL463914 | MANOALIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL111739 | CACOSPONGIONOLIDE B | IC50 | = | 4300.0 | nM | 5.37 |