Assay Detail
Binding
CHEMBL997271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat air pouch group2 sPLA2 at 10 uM by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipase A2, membrane associated (CHEMBL3686) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.43 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480681 | CACOSPONGIONOLIDE | — | 1 | 4.66 |
| CHEMBL111739 | CACOSPONGIONOLIDE B | — | 1 | 4.43 |
| CHEMBL463914 | MANOALIDE | — | 1 | 4.42 |
| CHEMBL480874 | CACOSPONGIONOLIDE E | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480681 | CACOSPONGIONOLIDE | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL111739 | CACOSPONGIONOLIDE B | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL463914 | MANOALIDE | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL480874 | CACOSPONGIONOLIDE E | IC50 | = | 65100.0 | nM | 4.19 |