Assay Detail
Functional
CHEMBL997578
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Antiproliferative activity against human SKOV3 cells by XTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.30 |
| CHEMBL455138 | — | — | 1 | 7.22 |
| CHEMBL510925 | — | — | 1 | 6.80 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 6.77 |
| CHEMBL455727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL455138 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL510925 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL455727 | — | IC50 | - | — | - |