Assay Detail
Binding
CHEMBL997699
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Displacement of [3H]ketanserin from human 5HT2A receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.91 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83081 | — | — | 1 | 8.12 |
| CHEMBL47482 | — | — | 1 | 7.70 |
| CHEMBL454491 | — | — | 1 | 6.91 |
| CHEMBL497156 | — | — | 1 | 5.94 |
| CHEMBL497157 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83081 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL47482 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL454491 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL497156 | — | Ki | = | 1158.0 | nM | 5.94 |
| CHEMBL497157 | — | Ki | = | 1367.0 | nM | 5.86 |