Assay Detail
Functional
CHEMBL997705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human thrombopoietin receptor expressed in mouse Ba/F3 cells by kinase activation based reporter gene assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.90 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498173 | — | — | 1 | 7.68 |
| CHEMBL498581 | — | — | 1 | 7.60 |
| CHEMBL496123 | — | — | 1 | 7.58 |
| CHEMBL496122 | — | — | 1 | 7.43 |
| CHEMBL461101 | ELTROMBOPAG | 4.0 | 1 | 7.42 |
| CHEMBL522070 | — | — | 1 | 7.29 |
| CHEMBL496950 | — | — | 1 | 7.07 |
| CHEMBL477195 | — | — | 1 | 6.96 |
| CHEMBL525732 | — | — | 1 | 6.96 |
| CHEMBL496755 | — | — | 1 | 6.94 |
| CHEMBL525533 | — | — | 1 | 6.93 |
| CHEMBL497793 | — | — | 1 | 6.80 |
| CHEMBL525906 | — | — | 1 | 6.80 |
| CHEMBL497349 | — | — | 1 | 6.75 |
| CHEMBL495731 | — | — | 1 | 6.64 |
| CHEMBL522391 | — | — | 1 | 6.56 |
| CHEMBL497149 | — | — | 1 | 6.42 |
| CHEMBL497372 | — | — | 1 | 6.35 |
| CHEMBL526077 | — | — | 1 | 5.90 |
| CHEMBL497582 | — | — | 1 | 5.84 |
| CHEMBL497583 | — | — | 1 | - |
| CHEMBL497348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498173 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL498581 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL496123 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL496122 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL461101 | ELTROMBOPAG | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL522070 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL496950 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL477195 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL525732 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL496755 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL525533 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL497793 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL525906 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL497349 | — | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL495731 | — | EC50 | = | 228.0 | nM | 6.64 |
| CHEMBL522391 | — | EC50 | = | 277.0 | nM | 6.56 |
| CHEMBL497149 | — | EC50 | = | 376.0 | nM | 6.42 |
| CHEMBL497372 | — | EC50 | = | 449.0 | nM | 6.35 |
| CHEMBL526077 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL497582 | — | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL497583 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL497348 | — | EC50 | > | 1000.0 | nM | - |