Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL997779

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human Wee1 (215-647) expressed in baculovirus
ChEMBL ↗
194
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

3D-QSAR studies of Checkpoint Kinase Weel inhibitors based on molecular docking, CoMFA and CoMSIA.
Yi P, Fang X, Qiu M.
Eur J Med Chem (2008) 43 : 925 -938
PubMed 17698256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 194 6.60 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL379975 — — 2 7.96
CHEMBL213585 — — 2 7.92
CHEMBL215815 — — 2 7.89
CHEMBL215485 — — 2 7.82
CHEMBL386048 — — 2 7.75
CHEMBL384089 — — 2 7.72
CHEMBL378066 — — 2 7.70
CHEMBL211140 — — 2 7.70
CHEMBL213313 — — 2 7.68
CHEMBL215677 — — 2 7.64
CHEMBL1163003 — — 2 7.64
CHEMBL213075 — — 2 7.62
CHEMBL209594 — — 2 7.62
CHEMBL386199 — — 2 7.57
CHEMBL213593 — — 2 7.55
CHEMBL384477 — — 2 7.55
CHEMBL214090 — — 2 7.54
CHEMBL215506 — — 2 7.48
CHEMBL386398 — — 2 7.48
CHEMBL378067 — — 2 7.46
CHEMBL213422 — — 2 7.42
CHEMBL377839 — — 2 7.38
CHEMBL214208 — — 2 7.38
CHEMBL379732 — — 2 7.35
CHEMBL209786 — — 2 7.33
CHEMBL379392 — — 2 7.31
CHEMBL379825 — — 2 7.30
CHEMBL212646 — — 2 7.30
CHEMBL213525 — — 2 7.28
CHEMBL212495 — — 2 7.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL379975 — IC50 = 11.0 nM 7.96
CHEMBL379975 — IC50 = 10.99 nM 7.96
CHEMBL213585 — IC50 = 12.0 nM 7.92
CHEMBL213585 — IC50 = 11.99 nM 7.92
CHEMBL215815 — IC50 = 13.0 nM 7.89
CHEMBL215815 — IC50 = 13.0 nM 7.89
CHEMBL215485 — IC50 = 15.0 nM 7.82
CHEMBL215485 — IC50 = 15.0 nM 7.82
CHEMBL386048 — IC50 = 17.99 nM 7.75
CHEMBL386048 — IC50 = 18.0 nM 7.75
CHEMBL384089 — IC50 = 19.01 nM 7.72
CHEMBL384089 — IC50 = 19.0 nM 7.72
CHEMBL378066 — IC50 = 20.0 nM 7.70
CHEMBL211140 — IC50 = 20.0 nM 7.70
CHEMBL211140 — IC50 = 20.0 nM 7.70
CHEMBL378066 — IC50 = 20.0 nM 7.70
CHEMBL213313 — IC50 = 20.99 nM 7.68
CHEMBL1163003 — IC50 = 23.0 nM 7.64
CHEMBL215677 — IC50 = 23.01 nM 7.64
CHEMBL1163003 — IC50 = 23.01 nM 7.64
CHEMBL215677 — IC50 = 23.0 nM 7.64
CHEMBL209594 — IC50 = 24.0 nM 7.62
CHEMBL209594 — IC50 = 23.99 nM 7.62
CHEMBL213075 — IC50 = 24.0 nM 7.62
CHEMBL213075 — IC50 = 23.99 nM 7.62
CHEMBL213313 — IC50 = 24.0 nM 7.62
CHEMBL386199 — IC50 = 27.0 nM 7.57
CHEMBL386199 — IC50 = 26.98 nM 7.57
CHEMBL384477 — IC50 = 28.0 nM 7.55
CHEMBL213593 — IC50 = 27.99 nM 7.55
CHEMBL384477 — IC50 = 27.99 nM 7.55
CHEMBL213593 — IC50 = 28.0 nM 7.55
CHEMBL214090 — IC50 = 29.0 nM 7.54
CHEMBL214090 — IC50 = 28.97 nM 7.54
CHEMBL386398 — IC50 = 33.04 nM 7.48
CHEMBL215506 — IC50 = 33.04 nM 7.48
CHEMBL215506 — IC50 = 33.0 nM 7.48
CHEMBL386398 — IC50 = 33.0 nM 7.48
CHEMBL378067 — IC50 = 34.99 nM 7.46
CHEMBL378067 — IC50 = 35.0 nM 7.46
CHEMBL213422 — IC50 = 38.02 nM 7.42
CHEMBL213422 — IC50 = 38.0 nM 7.42
CHEMBL377839 — IC50 = 42.0 nM 7.38
CHEMBL214208 — IC50 = 42.0 nM 7.38
CHEMBL214208 — IC50 = 41.98 nM 7.38
CHEMBL377839 — IC50 = 41.98 nM 7.38
CHEMBL379732 — IC50 = 45.0 nM 7.35
CHEMBL379732 — IC50 = 44.98 nM 7.35
CHEMBL209786 — IC50 = 46.99 nM 7.33
CHEMBL209786 — IC50 = 47.0 nM 7.33