Assay Detail
Binding
CHEMBL997786
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Inhibition of CDK2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260416 | — | — | 1 | 8.70 |
| CHEMBL500804 | — | — | 1 | 8.30 |
| CHEMBL427909 | — | — | 1 | 8.30 |
| CHEMBL260417 | — | — | 1 | 8.30 |
| CHEMBL407981 | — | — | 1 | 7.22 |
| CHEMBL318522 | — | — | 1 | 6.47 |
| CHEMBL260928 | — | — | 1 | 6.32 |
| CHEMBL260929 | — | — | 1 | 6.30 |
| CHEMBL421207 | — | — | 1 | 6.20 |
| CHEMBL260231 | — | — | 1 | 6.19 |
| CHEMBL259270 | — | — | 1 | - |
| CHEMBL317657 | — | — | 1 | - |
| CHEMBL101747 | — | — | 1 | - |
| CHEMBL406644 | — | — | 1 | - |
| CHEMBL261690 | — | — | 1 | - |
| CHEMBL408564 | — | — | 1 | - |
| CHEMBL101804 | — | — | 1 | - |
| CHEMBL407980 | — | — | 1 | - |
| CHEMBL260243 | — | — | 1 | - |
| CHEMBL261660 | — | — | 1 | - |
| CHEMBL407113 | — | — | 1 | - |
| CHEMBL261659 | — | — | 1 | - |
| CHEMBL405021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260416 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL500804 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL427909 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL260417 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL407981 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL318522 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL260928 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL260929 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL421207 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL260231 | — | IC50 | = | 639.0 | nM | 6.19 |
| CHEMBL259270 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL317657 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL101747 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL406644 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL261690 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL408564 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL101804 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL407980 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL260243 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL261660 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL407113 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL261659 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL405021 | — | IC50 | > | 1000.0 | nM | - |