Assay Detail
Binding
CHEMBL998002
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Inhibition of His-tagged human recombinant 2N4R tau protein aggregation assessed as inhibition octadecyl sulphate-induced fibrillation by filter trap assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of cyanine tau aggregation inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.86 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466853 | — | — | 1 | 6.55 |
| CHEMBL466420 | — | — | 1 | 6.54 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 6.21 |
| CHEMBL468934 | — | — | 1 | 6.05 |
| CHEMBL81782 | — | — | 1 | 6.02 |
| CHEMBL467894 | — | — | 1 | 6.01 |
| CHEMBL421701 | DITHIAZANINE IODIDE | 4.0 | 1 | 5.67 |
| CHEMBL511238 | — | — | 1 | 5.59 |
| CHEMBL469145 | — | — | 1 | 5.48 |
| CHEMBL82134 | — | — | 1 | 5.30 |
| CHEMBL467886 | — | — | 1 | 5.00 |
| CHEMBL444383 | — | — | 1 | - |
| CHEMBL467895 | — | — | 1 | - |
| CHEMBL79003 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466853 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL466420 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL468934 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL81782 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL467894 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL421701 | DITHIAZANINE IODIDE | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL511238 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL469145 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL82134 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL467886 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL444383 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL467895 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL79003 | — | IC50 | > | 10000.0 | nM | - |