Assay Detail
Binding
CHEMBL998270
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Inhibition of human COX2 expressed in sf9 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.16 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.10 |
| CHEMBL446323 | 3,4-DIHYDROXYXANTHONE | — | 1 | 5.72 |
| CHEMBL463769 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL118 | CELECOXIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL446323 | 3,4-DIHYDROXYXANTHONE | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL463769 | — | IC50 | = | 2990.0 | nM | 5.52 |