Assay Detail
Functional
CHEMBL998398
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Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BHK-21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.85 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524883 | — | — | 1 | 6.50 |
| CHEMBL526383 | — | — | 1 | 6.36 |
| CHEMBL463175 | CEPHALOCHROMIN | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524883 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL526383 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL463175 | CEPHALOCHROMIN | IC50 | = | 20000.0 | nM | 4.70 |