Assay Detail
Binding
CHEMBL998517
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Inhibition of human IMPDH2
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mycophenolic acid analogs with a modified metabolic profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.57 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | 4.0 | 1 | 8.00 |
| CHEMBL443417 | — | — | 2 | 5.64 |
| CHEMBL486325 | — | — | 1 | 5.06 |
| CHEMBL444502 | — | — | 1 | 4.84 |
| CHEMBL487565 | — | — | 1 | 4.52 |
| CHEMBL487564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL866 | MYCOPHENOLIC ACID | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL443417 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL443417 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL486325 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL444502 | — | Ki | = | 14300.0 | nM | 4.84 |
| CHEMBL487565 | — | Ki | = | 30100.0 | nM | 4.52 |
| CHEMBL487564 | — | Ki | > | 100000.0 | nM | - |