Assay Detail
Functional
CHEMBL998520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist-enhancing activity in epsilon-epitope tagged TRPV1 receptor expressed in mouse NIH3T3 cells assessed as capsaicin-induced 45Ca2+ influx by microplate liquid scintillation counter
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.58 | 4.77 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485726 | — | — | 1 | 4.77 |
| CHEMBL109081 | — | — | 1 | 4.67 |
| CHEMBL470161 | — | — | 1 | 4.66 |
| CHEMBL323042 | — | — | 1 | 4.65 |
| CHEMBL505916 | — | — | 1 | 4.57 |
| CHEMBL469757 | — | — | 1 | 4.56 |
| CHEMBL511970 | — | — | 1 | 4.55 |
| CHEMBL108801 | — | — | 1 | 4.55 |
| CHEMBL485925 | — | — | 1 | 4.54 |
| CHEMBL472235 | — | — | 1 | 4.29 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | - |
| CHEMBL283013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485726 | — | EC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL109081 | — | EC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL470161 | — | EC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL323042 | — | EC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL505916 | — | EC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL469757 | — | EC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL511970 | — | EC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL108801 | — | EC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL485925 | — | EC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL472235 | — | EC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL1484 | NICARDIPINE | Activity | - | — | - | |
| CHEMBL283013 | — | Activity | - | — | - |