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Assay Detail

CHEMBL998577

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Binding
Inhibition of the ATP-mediated HIV1 reverse transcriptase D67N/K70R/T215F/K219Q mutant catalyzed 3'-azido, 3'-deoxythymidine excision from AZT-terminated DNA primers
ChEMBL ↗
70
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.
Song Y, Chan JM, Tovian Z, Secrest A, Nagy E, Krysiak K, Bergan K, Parniak MA, Oldfield E.
Bioorg Med Chem (2008) 16 : 8959 -8967
PubMed 18789701 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 70 5.46 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL34249 — — 2 6.30
CHEMBL194213 — — 2 6.10
CHEMBL370662 — — 2 6.00
CHEMBL197173 — — 2 6.00
CHEMBL192881 — — 2 5.90
CHEMBL198014 — — 2 5.82
CHEMBL194801 — — 2 5.72
CHEMBL194800 — — 2 5.70
CHEMBL196254 — — 2 5.70
CHEMBL195956 — — 2 5.62
CHEMBL194302 — — 2 5.54
CHEMBL55371 — — 2 5.50
CHEMBL425748 — — 2 5.50
CHEMBL198013 — — 2 5.50
CHEMBL198439 — — 2 5.41
CHEMBL436758 — — 2 5.41
CHEMBL382291 — — 2 5.34
CHEMBL370330 — — 2 5.30
CHEMBL196554 — — 2 5.30
CHEMBL198066 — — 2 5.30
CHEMBL443750 — — 2 5.10
CHEMBL198409 — — 2 5.02
CHEMBL381465 — — 2 5.00
CHEMBL414849 — — 2 4.42
CHEMBL426281 — — 2 4.30
CHEMBL55214 NERIDRONIC ACID 3.0 2 -
CHEMBL56556 — — 2 -
CHEMBL416301 — — 2 -
CHEMBL54004 — — 2 -
CHEMBL54537 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL34249 — IC50 = 501.19 nM 6.30
CHEMBL34249 — IC50 = 500.0 nM 6.30
CHEMBL194213 — IC50 = 794.33 nM 6.10
CHEMBL194213 — IC50 = 900.0 nM 6.05
CHEMBL197173 — IC50 = 1000.0 nM 6.00
CHEMBL370662 — IC50 = 1000.0 nM 6.00
CHEMBL370662 — IC50 = 1000.0 nM 6.00
CHEMBL197173 — IC50 = 1000.0 nM 6.00
CHEMBL192881 — IC50 = 1258.93 nM 5.90
CHEMBL192881 — IC50 = 1300.0 nM 5.89
CHEMBL198014 — IC50 = 1500.0 nM 5.82
CHEMBL198014 — IC50 = 1584.89 nM 5.80
CHEMBL194801 — IC50 = 1900.0 nM 5.72
CHEMBL196254 — IC50 = 1995.26 nM 5.70
CHEMBL194800 — IC50 = 1995.26 nM 5.70
CHEMBL194801 — IC50 = 1995.26 nM 5.70
CHEMBL194800 — IC50 = 2100.0 nM 5.68
CHEMBL196254 — IC50 = 2200.0 nM 5.66
CHEMBL195956 — IC50 = 2400.0 nM 5.62
CHEMBL195956 — IC50 = 2511.89 nM 5.60
CHEMBL194302 — IC50 = 2900.0 nM 5.54
CHEMBL194302 — IC50 = 3162.28 nM 5.50
CHEMBL55371 — IC50 = 3162.28 nM 5.50
CHEMBL198013 — IC50 = 3162.28 nM 5.50
CHEMBL55371 — IC50 = 3200.0 nM 5.50
CHEMBL425748 — IC50 = 3162.28 nM 5.50
CHEMBL425748 — IC50 = 3300.0 nM 5.48
CHEMBL198013 — IC50 = 3500.0 nM 5.46
CHEMBL198439 — IC50 = 3900.0 nM 5.41
CHEMBL436758 — IC50 = 3900.0 nM 5.41
CHEMBL198439 — IC50 = 3981.07 nM 5.40
CHEMBL436758 — IC50 = 3981.07 nM 5.40
CHEMBL382291 — IC50 = 4600.0 nM 5.34
CHEMBL382291 — IC50 = 5011.87 nM 5.30
CHEMBL370330 — IC50 = 5000.0 nM 5.30
CHEMBL370330 — IC50 = 5011.87 nM 5.30
CHEMBL198066 — IC50 = 5011.87 nM 5.30
CHEMBL196554 — IC50 = 5011.87 nM 5.30
CHEMBL198066 — IC50 = 5200.0 nM 5.28
CHEMBL196554 — IC50 = 5400.0 nM 5.27
CHEMBL443750 — IC50 = 7943.28 nM 5.10
CHEMBL443750 — IC50 = 7900.0 nM 5.10
CHEMBL198409 — IC50 = 9500.0 nM 5.02
CHEMBL381465 — IC50 = 10000.0 nM 5.00
CHEMBL198409 — IC50 = 10000.0 nM 5.00
CHEMBL381465 — IC50 = 11200.0 nM 4.95
CHEMBL414849 — IC50 = 38000.0 nM 4.42
CHEMBL414849 — IC50 = 39810.72 nM 4.40
CHEMBL426281 — IC50 = 50118.72 nM 4.30
CHEMBL426281 — IC50 = 51300.0 nM 4.29