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Assay Detail

CHEMBL998579

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Toxicity against human SF268 cells assessed as growth inhibition by broth microdilution method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type SF-268
Confidence 1 — Organism
Curated By Autocuration

Target

SF-268 (CHEMBL613977)
Type CELL-LINE
Organism Homo sapiens

Publication

Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.
Song Y, Chan JM, Tovian Z, Secrest A, Nagy E, Krysiak K, Bergan K, Parniak MA, Oldfield E.
Bioorg Med Chem (2008) 16 : 8959 -8967
PubMed 18789701 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.17 4.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194213 1 4.32
CHEMBL382291 1 4.02
CHEMBL370662 1 -
CHEMBL197173 1 -
CHEMBL192881 1 -
CHEMBL198014 1 -
CHEMBL194801 1 -
CHEMBL194800 1 -
CHEMBL196254 1 -
CHEMBL195956 1 -
CHEMBL194302 1 -
CHEMBL55371 1 -
CHEMBL425748 1 -
CHEMBL198013 1 -
CHEMBL436758 1 -
CHEMBL198439 1 -
CHEMBL370330 1 -
CHEMBL198066 1 -
CHEMBL196554 1 -
CHEMBL443750 1 -
CHEMBL198409 1 -
CHEMBL381465 1 -
CHEMBL414849 1 -
CHEMBL34249 1 -
CHEMBL426281 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194213 IC50 = 48000.0 nM 4.32
CHEMBL382291 IC50 = 95000.0 nM 4.02
CHEMBL370662 IC50 > 300000.0 nM -
CHEMBL197173 IC50 = 236000.0 nM -
CHEMBL192881 IC50 = 225000.0 nM -
CHEMBL198014 IC50 = 122000.0 nM -
CHEMBL194801 IC50 = 224000.0 nM -
CHEMBL194800 IC50 > 300000.0 nM -
CHEMBL196254 IC50 > 100000.0 nM -
CHEMBL195956 IC50 = 139000.0 nM -
CHEMBL194302 IC50 > 300000.0 nM -
CHEMBL55371 IC50 = 269000.0 nM -
CHEMBL425748 IC50 = 176000.0 nM -
CHEMBL198013 IC50 > 100000.0 nM -
CHEMBL436758 IC50 > 100000.0 nM -
CHEMBL198439 IC50 > 300000.0 nM -
CHEMBL370330 IC50 = 297000.0 nM -
CHEMBL198066 IC50 - -
CHEMBL196554 IC50 > 300000.0 nM -
CHEMBL443750 IC50 > 300000.0 nM -
CHEMBL198409 IC50 > 300000.0 nM -
CHEMBL381465 IC50 > 300000.0 nM -
CHEMBL414849 IC50 = 186000.0 nM -
CHEMBL34249 IC50 = 208000.0 nM -
CHEMBL426281 IC50 > 300000.0 nM -