Assay Detail
Toxicity
CHEMBL998580
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Toxicity against human NCI-H460 cells assessed as growth inhibition by broth microdilution method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.22 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194213 | — | — | 1 | 4.41 |
| CHEMBL382291 | — | — | 1 | 4.02 |
| CHEMBL370662 | — | — | 1 | - |
| CHEMBL197173 | — | — | 1 | - |
| CHEMBL192881 | — | — | 1 | - |
| CHEMBL198014 | — | — | 1 | - |
| CHEMBL194801 | — | — | 1 | - |
| CHEMBL194800 | — | — | 1 | - |
| CHEMBL196254 | — | — | 1 | - |
| CHEMBL195956 | — | — | 1 | - |
| CHEMBL194302 | — | — | 1 | - |
| CHEMBL55371 | — | — | 1 | - |
| CHEMBL425748 | — | — | 1 | - |
| CHEMBL198013 | — | — | 1 | - |
| CHEMBL436758 | — | — | 1 | - |
| CHEMBL198439 | — | — | 1 | - |
| CHEMBL370330 | — | — | 1 | - |
| CHEMBL198066 | — | — | 1 | - |
| CHEMBL196554 | — | — | 1 | - |
| CHEMBL443750 | — | — | 1 | - |
| CHEMBL198409 | — | — | 1 | - |
| CHEMBL381465 | — | — | 1 | - |
| CHEMBL414849 | — | — | 1 | - |
| CHEMBL34249 | — | — | 1 | - |
| CHEMBL426281 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194213 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL382291 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL370662 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL197173 | — | IC50 | = | 253000.0 | nM | - |
| CHEMBL192881 | — | IC50 | = | 248000.0 | nM | - |
| CHEMBL198014 | — | IC50 | = | 141000.0 | nM | - |
| CHEMBL194801 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL194800 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL196254 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195956 | — | IC50 | = | 118000.0 | nM | - |
| CHEMBL194302 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL55371 | — | IC50 | = | 253000.0 | nM | - |
| CHEMBL425748 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL198013 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL436758 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL198439 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL370330 | — | IC50 | = | 301000.0 | nM | - |
| CHEMBL198066 | — | IC50 | - | — | - | |
| CHEMBL196554 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL443750 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL198409 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL381465 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL414849 | — | IC50 | = | 187000.0 | nM | - |
| CHEMBL34249 | — | IC50 | = | 241000.0 | nM | - |
| CHEMBL426281 | — | IC50 | > | 300000.0 | nM | - |