Assay Detail
Binding
CHEMBL998623
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Inhibition of PLD1 in human Calu1 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Calu-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.93 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471056 | — | — | 1 | 7.60 |
| CHEMBL471257 | — | — | 1 | 6.82 |
| CHEMBL511648 | — | — | 1 | 6.82 |
| CHEMBL511475 | — | — | 1 | 6.00 |
| CHEMBL471054 | — | — | 1 | 5.72 |
| CHEMBL471055 | — | — | 1 | 5.68 |
| CHEMBL471259 | — | — | 1 | 5.58 |
| CHEMBL513060 | — | — | 1 | 5.47 |
| CHEMBL339069 | — | — | 1 | 5.44 |
| CHEMBL18094 | — | — | 1 | 5.44 |
| CHEMBL471258 | — | — | 1 | 5.37 |
| CHEMBL471261 | — | — | 1 | 5.23 |
| CHEMBL470847 | — | — | 1 | - |
| CHEMBL471463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471056 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL471257 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL511648 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL511475 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL471054 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL471055 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL471259 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL513060 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL339069 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL18094 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL471258 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL471261 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL470847 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL471463 | — | IC50 | > | 20000.0 | nM | - |