Assay Detail
Functional
CHEMBL998652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNFalpha production in whole blood
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Blood |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Current perspective of TACE inhibitors: a review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.06 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134908 | — | — | 1 | 7.70 |
| CHEMBL401263 | — | — | 1 | 7.62 |
| CHEMBL489100 | — | — | 1 | 7.05 |
| CHEMBL271235 | — | — | 1 | 6.96 |
| CHEMBL253088 | — | — | 1 | 6.89 |
| CHEMBL184885 | — | — | 1 | 6.75 |
| CHEMBL148169 | — | — | 1 | 6.46 |
| CHEMBL491084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134908 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL401263 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL489100 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL271235 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL253088 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL184885 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL148169 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL491084 | — | IC50 | > | 50000.0 | nM | - |