Assay Detail
Binding
CHEMBL998726
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Inhibition of HIV1 integrase 3'-processing activity
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.04 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | 4.0 | 1 | 7.30 |
| CHEMBL522229 | — | — | 1 | 4.78 |
| CHEMBL458483 | — | — | 1 | - |
| CHEMBL497489 | — | — | 1 | - |
| CHEMBL526269 | — | — | 1 | - |
| CHEMBL498491 | — | — | 1 | - |
| CHEMBL496491 | — | — | 1 | - |
| CHEMBL496476 | — | — | 1 | - |
| CHEMBL497506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL204656 | ELVITEGRAVIR | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL522229 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL458483 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL497489 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL526269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL498491 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL496491 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL496476 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL497506 | — | IC50 | > | 100000.0 | nM | - |