Assay Detail
Functional
CHEMBL998807
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Antileishmanial activity against Leishmania major DESTO promastigotes after 72 hrs
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cycloartane triterpenoids from Astragalus bicuspis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.82 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.27 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.37 |
| CHEMBL500607 | — | — | 1 | 4.25 |
| CHEMBL501026 | — | — | 1 | 4.19 |
| CHEMBL450438 | — | — | 1 | 4.03 |
| CHEMBL504655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL500607 | — | IC50 | = | 56510.0 | nM | 4.25 |
| CHEMBL501026 | — | IC50 | = | 64350.0 | nM | 4.19 |
| CHEMBL450438 | — | IC50 | = | 93650.0 | nM | 4.03 |
| CHEMBL504655 | — | IC50 | = | 107570.0 | nM | - |