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Assay Detail

CHEMBL998935

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant furin-dependent anthrax protective antigen processing
30
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Furin (CHEMBL2611)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modeling the activity of furin inhibitors using artificial neural network.
Worachartcheewan A, Nantasenamat C, Naenna T, Isarankura-Na-Ayudhya C, Prachayasittikul V.
Eur J Med Chem (2009) 44 : 1664 -1673
PubMed 18977558 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 30 6.01 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL488769 2 8.22
CHEMBL485694 2 7.92
CHEMBL522615 2 7.66
CHEMBL487946 2 7.38
CHEMBL506022 2 7.34
CHEMBL505581 2 7.16
CHEMBL490273 2 7.05
CHEMBL205548 2 6.77
CHEMBL448513 2 6.39
CHEMBL451882 2 6.37
CHEMBL451430 2 6.09
CHEMBL506831 2 5.75
CHEMBL487131 1 4.00
CHEMBL487333 1 4.00
CHEMBL519572 1 4.00
CHEMBL488574 1 4.00
CHEMBL261020 1 4.00
CHEMBL508352 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL488769 Ki = 6.0 nM 8.22
CHEMBL485694 Ki = 12.0 nM 7.92
CHEMBL522615 Ki = 22.0 nM 7.66
CHEMBL487946 Ki = 42.0 nM 7.38
CHEMBL506022 Ki = 46.0 nM 7.34
CHEMBL505581 Ki = 69.0 nM 7.16
CHEMBL490273 Ki = 89.0 nM 7.05
CHEMBL205548 Ki = 169.0 nM 6.77
CHEMBL448513 Ki = 404.0 nM 6.39
CHEMBL451882 Ki = 423.0 nM 6.37
CHEMBL451430 Ki = 812.0 nM 6.09
CHEMBL506831 Ki = 1768.0 nM 5.75
CHEMBL519572 Ki = 100000.0 nM 4.00
CHEMBL487131 Ki = 100000.0 nM 4.00
CHEMBL487333 Ki = 100000.0 nM 4.00
CHEMBL261020 Ki = 100000.0 nM 4.00
CHEMBL508352 Ki = 100000.0 nM 4.00
CHEMBL488574 Ki = 100000.0 nM 4.00
CHEMBL205548 Ki = 169824365.25 nM -
CHEMBL490273 Ki = 89125093.81 nM -
CHEMBL448513 Ki = 407380277.8 nM -
CHEMBL522615 Ki = 21877616.24 nM -
CHEMBL488769 Ki = 6025595.86 nM -
CHEMBL505581 Ki = 69183097.09 nM -
CHEMBL485694 Ki = 12022644.35 nM -
CHEMBL487946 Ki = 41686938.35 nM -
CHEMBL506022 Ki = 45708818.96 nM -
CHEMBL451882 Ki = 426579518.8 nM -
CHEMBL451430 Ki = 812830516.16 nM -
CHEMBL506831 Ki = 562341325.19 nM -