Assay Detail
Functional
CHEMBL999128
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PGF2apha production in arachidonic acid-stimulated mouse MC9 cells
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MC9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.35 | 6.52 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.52 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 6.48 |
| CHEMBL272342 | EFIPLADIB | 2.0 | 1 | 6.05 |
| CHEMBL26915 | SC-560 | — | 1 | - |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | - |
| CHEMBL404529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL154 | NAPROXEN | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL272342 | EFIPLADIB | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL26915 | SC-560 | IC50 | < | 5.0 | nM | - |
| CHEMBL93 | ZILEUTON | Activity | - | — | - | |
| CHEMBL404529 | — | IC50 | > | 1000.0 | nM | - |