Assay Detail
Binding
CHEMBL999228
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Inhibition of rat liver squalene synthase by liqiud scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.06 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504845 | ZARAGOZIC ACID B | — | 1 | 9.70 |
| CHEMBL505374 | ZARAGOZIC ACID C | — | 1 | 9.40 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | — | 1 | 9.30 |
| CHEMBL502210 | ZARAGOZIC ACID D2 | — | 1 | 8.70 |
| CHEMBL502872 | ZARAGOZIC ACID D | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504845 | ZARAGOZIC ACID B | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL505374 | ZARAGOZIC ACID C | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL280978 | ZARAGOZIC ACIDS A | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL502210 | ZARAGOZIC ACID D2 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL502872 | ZARAGOZIC ACID D | IC50 | = | 6.0 | nM | 8.22 |