Assay Detail
Functional
CHEMBL999407
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Cytotoxicity against human A549 cells after 72 hrs by XTT assay
20
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.98 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 2 | 8.52 |
| CHEMBL410946 | — | — | 2 | 7.37 |
| CHEMBL526640 | — | — | 2 | 5.92 |
| CHEMBL247386 | — | — | 2 | 5.77 |
| CHEMBL497377 | — | — | 2 | 5.00 |
| CHEMBL443991 | — | — | 1 | 5.00 |
| CHEMBL497379 | — | — | 1 | 5.00 |
| CHEMBL503981 | — | — | 2 | 5.00 |
| CHEMBL488982 | — | — | 2 | 5.00 |
| CHEMBL489193 | — | — | 2 | 5.00 |
| CHEMBL482407 | — | — | 2 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL410946 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL410946 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL526640 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL247386 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL482407 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL443991 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL497377 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL489193 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL488982 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL503981 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL497379 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL497377 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL247386 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL526640 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL503981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL488982 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489193 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL482407 | — | IC50 | > | 10000.0 | nM | - |