Assay Detail
Functional
CHEMBL999469
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Agonist activity at human GPR40 expressed in T-REx HEK293 cells assessed as effect on intracellular calcium concentration by FLIPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.89 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8739 | LINOLENIC ACID | — | 1 | 5.28 |
| CHEMBL463785 | — | — | 1 | 4.72 |
| CHEMBL515995 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8739 | LINOLENIC ACID | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL463785 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL515995 | — | EC50 | = | 21000.0 | nM | 4.68 |