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Assay Detail

CHEMBL999603

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]rolipram from PDE4 by RBA
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Kodimuthali A, Jabaris SS, Pal M.
J Med Chem (2008) 51 : 5471 -5489
PubMed 18686943 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 7 6.68 7.80
IC50 4 6.82 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL32442 CDP840 1 7.80
CHEMBL449708 1 7.60
CHEMBL40200 1 7.11
CHEMBL453093 1 7.08
CHEMBL70391 1 6.83
CHEMBL250546 SCH-351591 1 6.82
CHEMBL453357 1 6.57
CHEMBL81364 1 6.42
CHEMBL39058 1 6.28
CHEMBL99494 1 5.99
CHEMBL301351 1 5.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL32442 CDP840 Ki = 16.0 nM 7.80
CHEMBL449708 Ki = 25.0 nM 7.60
CHEMBL40200 IC50 = 77.0 nM 7.11
CHEMBL453093 IC50 = 84.0 nM 7.08
CHEMBL70391 Ki = 149.0 nM 6.83
CHEMBL250546 SCH-351591 IC50 = 150.0 nM 6.82
CHEMBL453357 Ki = 271.0 nM 6.57
CHEMBL81364 Ki = 383.0 nM 6.42
CHEMBL39058 IC50 = 530.0 nM 6.28
CHEMBL99494 Ki = 1020.0 nM 5.99
CHEMBL301351 Ki = 2800.0 nM 5.55