Compound Detail
CHEMBL100486
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Basic Information
| ChEMBL ID | CHEMBL100486 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UHOAIESFARWLTF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
298.8
MW (Da)
2.87
ALogP
3
HBA
0
HBD
23.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.68
Kd 1 meas. best 5.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL3943 | Kd | 5.6 | 5.6 | 2511.9 | 1 |
| Histamine H1 receptor CHEMBL3943 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | Kd | = | 2511.89 | nM | 5.6 | In vitro for histamine H1 receptor antagonist activity against histamine-induced... | 1353796 |
| Histamine H1 receptor | IC50 | = | 21000.0 | nM | 4.68 | In vitro for histamine H1 receptor antagonist activity against histamine-induced... | 1353796 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1353796 | 10.1021/jm00093a025 | Histamine H1 receptor | 2 |
Data from ChEMBL 36 via Core Engine