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Compound Detail

CHEMBL1067

LICARBAZEPINE
🧪 Phase III
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🧪 Phase III
NC(=O)N1c2ccccc2CC(O)c2ccccc21

Basic Information

ChEMBL ID CHEMBL1067
Name LICARBAZEPINE
Phase Phase III
Structure Type MOL
InChI Key BMPDWHIDQYTSHX-UHFFFAOYSA-N

Known Names

10-hydroxy-carbamazepine Licarbazepina Licarbazepine
0
Targets
0
Activities
0
Assay Types
16
PK Parameters
12
Publications
3
Known Names
3
Indications

Molecular Properties

254.3
MW (Da)
2.49
ALogP
2
HBA
2
HBD
66.6
PSA (Ų)
0.76
QED
0
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Racemic
USAN Stem -pine

Extended Properties

Molecular Formula C15H14N2O2
MW 254.29
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness 0.06

Indications

Bipolar Disorder Bipolar Disorder Epilepsy

Pharmacokinetic Data

Parameter Value Units Species
AUC 66267.97 ng.hr.mL-1 Homo sapiens
AUC 71226.63 ng.hr.mL-1 Homo sapiens
AUC 36210.9 ng.hr.mL-1 Homo sapiens
AUC 27768.47 ng.hr.mL-1 Homo sapiens
CL 1.5 L/hr Homo sapiens
CL 1.7 L/hr Homo sapiens
CL 1.31 L/hr Homo sapiens
CL 3.51 L/hr Homo sapiens
CL 5.52 L/hr Homo sapiens
CL 5.4 L/hr Homo sapiens
Excretion 49.0 % Homo sapiens
T1/2 9.0 hr Homo sapiens
T1/2 19.0 hr Homo sapiens
Tmax 0.25 hr Rattus norvegicus
Tmax 4.5 hr Homo sapiens
Vd(app) 49.0 L Homo sapiens

Literature References

PubMed DOI Target Context # Activities
21389120 10.1124/dmd.109.030593 Homo sapiens 10
10411478 10.1021/jm980627g Rattus norvegicus 3
21389120 10.1124/dmd.109.030593 ADMET 3
24411477 10.1016/j.bmc.2013.12.035 P2X purinoceptor 4 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
10411478 10.1021/jm980627g Sodium channel protein type 8 subunit alpha 1
10411478 10.1021/jm980627g Unchecked 1
20958049 10.1021/jm100600y 5-hydroxytryptamine receptor 2B 1
21389120 10.1124/dmd.109.030593 No relevant target 1
21389120 10.1124/dmd.109.030593 Plasma 1
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 1

Data from ChEMBL 36 via Core Engine