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Compound Detail

CHEMBL1076644

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COc1cc([C@H]2c3cc4c(cc3[C@@H](OC(=O)CCC(=O)NCCCCNC(=O)[C@@H](C)c3cccc(C(=O)c5ccccc5)c3)[C@@H]3COC(=O)[C@@H]23)OCO4)cc(OC)c1OC

Basic Information

ChEMBL ID CHEMBL1076644
Phase Preclinical
Structure Type MOL
InChI Key VYMSOJINPHSSSE-UTLYFPIKSA-N
0
Targets
0
Activities
0
Assay Types
2
PK Parameters
11
Publications
0
Known Names

Molecular Properties

820.9
MW (Da)
5.79
ALogP
12
HBA
2
HBD
174.0
PSA (Ų)
0.07
QED
3
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C46H48N2O12
MW 820.89
Aromatic Rings 4
Heavy Atoms 60
NP-Likeness 0.50

Pharmacokinetic Data

Parameter Value Units Species
T1/2 24.0 hr -
T1/2 6.2 hr Mus musculus

Literature References

Data from ChEMBL 36 via Core Engine