Compound Detail
CHEMBL1081496
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Basic Information
| ChEMBL ID | CHEMBL1081496 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FESQXMPJZDBHFD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
323.8
MW (Da)
2.33
ALogP
7
HBA
0
HBD
66.3
PSA (Ų)
0.47
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 CHEMBL2094122 | Ki | 7.89 | 7.89 | 13.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 | Ki | = | 13.0 | nM | 7.89 | Displacement of [3H]Flumazenil from cloned human GABA alpha-5-beta-3-gamma-2 rec... | 19762240 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19762240 | 10.1016/j.bmcl.2009.08.053 | Unchecked | 3 |
| 19762240 | 10.1016/j.bmcl.2009.08.053 | GABA-A receptor; alpha-5/beta-3/gamma-2 | 1 |
| 19762240 | 10.1016/j.bmcl.2009.08.053 | GABA A receptor alpha-5/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine