Compound Detail
CHEMBL1086672
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CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1
Basic Information
| ChEMBL ID | CHEMBL1086672 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BNGYBTOLZSFSOV-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
461.6
MW (Da)
6.20
ALogP
4
HBA
3
HBD
82.4
PSA (Ų)
0.25
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.24
IC50 1 meas. best 8.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bombesin receptor subtype-3 CHEMBL1075140 | EC50 | 8.24 | 8.24 | 5.8 | 1 |
| Bombesin receptor subtype-3 CHEMBL4080 | IC50 | 8.21 | 8.21 | 6.1 | 1 |
| Bombesin receptor subtype-3 CHEMBL4080 | EC50 | 7.39 | 7.39 | 41.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bombesin receptor subtype-3 | EC50 | = | 5.8 | nM | 8.24 | Agonist activity at mouse BRS3 | 20347296 |
| Bombesin receptor subtype-3 | IC50 | = | 6.1 | nM | 8.21 | Binding affinity to human BRS3 | 20347296 |
| Bombesin receptor subtype-3 | EC50 | = | 41.0 | nM | 7.39 | Agonist activity at human BRS3 | 20347296 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20347296 | 10.1016/j.bmcl.2010.03.028 | Bombesin receptor subtype-3 | 5 |
| 20347296 | 10.1016/j.bmcl.2010.03.028 | Plasma | 1 |
| 20347296 | 10.1016/j.bmcl.2010.03.028 | Brain | 1 |
| 20347296 | 10.1016/j.bmcl.2010.03.028 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine