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Compound Detail

CHEMBL1088539

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CNC(=O)c1cc(Oc2ccc(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)cc2F)ccn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1088539
Phase Preclinical
Structure Type MOL
InChI Key QZPVUNCPIWFBDX-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

499.4
MW (Da)
4.83
ALogP
6
HBA
2
HBD
98.1
PSA (Ų)
0.37
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H17F4N5O3
MW 499.42
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -1.83

Literature References

PubMed DOI Target Context # Activities
20363625 10.1016/j.bmcl.2010.03.073 Macrophage-stimulating protein receptor 1
20363625 10.1016/j.bmcl.2010.03.073 Hepatocyte growth factor receptor 1
20363625 10.1016/j.bmcl.2010.03.073 Vascular endothelial growth factor receptor 2 1

Data from ChEMBL 36 via Core Engine