Compound Detail
CHEMBL1089523
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Basic Information
| ChEMBL ID | CHEMBL1089523 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KEVUKBLXWDZLED-UHFFFAOYSA-N |
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
3.75
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.72
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.24
IC50 1 meas. best 6.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bombesin receptor subtype-3 CHEMBL1075140 | EC50 | 7.24 | 7.1 | 57.0 | 2 |
| Bombesin receptor subtype-3 CHEMBL4080 | EC50 | 7.03 | 6.61 | 93.0 | 2 |
| Bombesin receptor subtype-3 CHEMBL4080 | IC50 | 6.41 | 6.41 | 390.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bombesin receptor subtype-3 | EC50 | = | 57.0 | nM | 7.24 | Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over ... | 20219372 |
| Bombesin receptor subtype-3 | EC50 | = | 93.0 | nM | 7.03 | Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over ... | 20219372 |
| Bombesin receptor subtype-3 | EC50 | = | 111.0 | nM | 6.96 | Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over ... | 20219372 |
| Bombesin receptor subtype-3 | IC50 | = | 390.0 | nM | 6.41 | Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 exp... | 20219372 |
| Bombesin receptor subtype-3 | EC50 | = | 641.0 | nM | 6.19 | Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over ... | 20219372 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20219372 | 10.1016/j.bmcl.2010.02.076 | Bombesin receptor subtype-3 | 5 |
Data from ChEMBL 36 via Core Engine