Compound Detail
CHEMBL1090366
AMINO(PHENYL)METHYLPHOSPHONIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1090366 |
| Name | AMINO(PHENYL)METHYLPHOSPHONIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZKFNOUUKULVDOB-UHFFFAOYSA-N |
1
Targets
8
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
187.1
MW (Da)
0.82
ALogP
2
HBA
3
HBD
83.5
PSA (Ų)
0.60
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 5.75
IC50 3 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 5.75 | 5.3 | 1800.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 1800.0 | nM | 5.75 | Inhibition of Streptococcus pneumoniae MetAP1a using Met-pNA as substrate | 25699713 |
| Unchecked | Ki | = | 6600.0 | nM | 5.18 | Inhibition of human MetAP1b F309M mutant using Met-pNA as substrate | 25699713 |
| Unchecked | Ki | = | 10600.0 | nM | 4.97 | Inhibition of Enterococcus faecalis MetAP1a using Met-pNA as substrate | 25699713 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25699713 | 10.1021/jm501790e | Unchecked | 4 |
| 20538467 | 10.1016/j.bmc.2010.04.050 | Receptor-type tyrosine-protein phosphatase alpha | 2 |
| 18399639 | 10.1021/jf800029t | Pyrroline-5-carboxylate reductase | 2 |
| 19697446 | 10.1002/ps.1830 | Glutamine synthetase, chloroplastic | 2 |
| 20347318 | 10.1016/j.bmc.2010.02.056 | Aminopeptidase N | 1 |
| 20538467 | 10.1016/j.bmc.2010.04.050 | Receptor-type tyrosine-protein phosphatase beta | 1 |
| 25699713 | 10.1021/jm501790e | Methionine aminopeptidase 1 | 1 |
Data from ChEMBL 36 via Core Engine