Compound Detail
CHEMBL1090406
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Basic Information
| ChEMBL ID | CHEMBL1090406 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XJXQJWGKRLKOFX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
327.8
MW (Da)
1.34
ALogP
4
HBA
2
HBD
86.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-secretase CHEMBL2094135 | IC50 | 6.25 | 5.655 | 557.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-secretase | IC50 | = | 557.0 | nM | 6.25 | Inhibition of gamma-secretase-mediated APP cleavage in human IMR-32 cells assess... | 20207136 |
| Gamma-secretase | IC50 | = | 8658.0 | nM | 5.06 | Inhibition of gamma-secretase-mediated notch cleavage in human IMR-32 cells afte... | 20207136 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20207136 | 10.1016/j.bmcl.2010.02.039 | Gamma-secretase | 4 |
| 20207136 | 10.1016/j.bmcl.2010.02.039 | Liver microsomes | 1 |
Data from ChEMBL 36 via Core Engine