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Compound Detail

CHEMBL1102

GLUTETHIMIDE
💊 Approved Drug
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💊 Approved Drug
CCC1(c2ccccc2)CCC(=O)NC1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1102
Name GLUTETHIMIDE
Phase Approved
Structure Type MOL
InChI Key JMBQKKAJIKAWKF-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Doriden Elrodorm Glutethimide Glutetimida Noxyron NSC-95239 Rigenox Sarodormin
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
20
Publications
8
Known Names
1
Mechanisms

Molecular Properties

217.3
MW (Da)
1.77
ALogP
2
HBA
1
HBD
46.2
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1976
Availability Discontinued
Chirality Racemic

Routes of Administration

Oral

Flags

Natural Product

Extended Properties

Molecular Formula C13H15NO2
MW 217.27
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness 0.02

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
GABA-A receptor; anion channel positive modulator POSITIVE MODULATOR GABA-A receptor; anion channel ✓ ✓

ATC Classification

N05CE01
glutethimide
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS

Literature References

PubMed DOI Target Context # Activities
1255670 10.1021/jm00225a023 Mus musculus 5
20014752 10.1021/tx900326k Hepatotoxicity 3
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 3
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 3
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
20185316 10.1016/j.bmc.2010.01.068 Toxoplasma gondii 1
20185316 10.1016/j.bmc.2010.01.068 NON-PROTEIN TARGET 1
20185316 10.1016/j.bmc.2010.01.068 Plasmodium falciparum 1
20185316 10.1016/j.bmc.2010.01.068 Pneumocystis carinii 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma brucei brucei 1
20185316 10.1016/j.bmc.2010.01.068 Trypanosoma cruzi 1
18834112 10.1021/jm800656v Amine oxidase [flavin-containing] B 1

Data from ChEMBL 36 via Core Engine