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Compound Detail

CHEMBL1104

EDROPHONIUM
💊 Approved Drug
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💊 Approved Drug
CC[N+](C)(C)c1cccc(O)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1104
Name EDROPHONIUM
Phase Approved
Structure Type MOL
InChI Key VWLHWLSRQJQWRG-UHFFFAOYSA-O
Therapeutic ✓ Yes

Known Names

Edrophonium Edrophonium cation Edrophonium ion Enlon-plus
0
Targets
0
Activities
0
Assay Types
1
PK Parameters
20
Publications
4
Known Names
2
Indications

Molecular Properties

166.2
MW (Da)
1.98
ALogP
1
HBA
1
HBD
20.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1951
Availability Discontinued
Chirality Achiral

Routes of Administration

Parenteral

Flags

Natural Product
USAN Stem -ium; -onium

Extended Properties

Molecular Formula C10H16NO+
MW 166.24
Aromatic Rings 1
Heavy Atoms 12
NP-Likeness 0.56

Indications

Hypotension, Orthostatic Orthostatic Intolerance

ATC Classification

V04CX07
edrophonium
Level 1: VARIOUS
Level 2: DIAGNOSTIC AGENTS

Pharmacokinetic Data

Parameter Value Units Species
CL 99.5 mL.min-1.g-1 Homo sapiens

Literature References

PubMed DOI Target Context # Activities
33606526 10.1021/acs.jmedchem.0c02047 POU domain, class 2, transcription factor 1 3
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
- 10.6019/CHEMBL4495565 SARS-CoV-2 2
- 10.6019/CHEMBL4651402 SARS-CoV-2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 1
37468498 10.1038/s41467-023-40064-9 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 1A 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent serotonin transporter 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 1
33606526 10.1021/acs.jmedchem.0c02047 Unchecked 1
38318365 10.1016/j.isci.2024.108907 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1

Data from ChEMBL 36 via Core Engine