Compound Detail
CHEMBL112402
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Basic Information
| ChEMBL ID | CHEMBL112402 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | INULNDODUCRGHF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
202.2
MW (Da)
-1.17
ALogP
6
HBA
4
HBD
129.8
PSA (Ų)
0.48
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas.
IC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 400.0 | nM | 6.4 | Tested in vitro for the concentration required to inhibit [3H]AMPA radioligand a... | 7523673 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7523673 | 10.1021/jm00046a009 | Glutamate NMDA receptor | 2 |
| 7523673 | 10.1021/jm00046a009 | Glutamate receptor ionotropic, AMPA | 1 |
| 7523673 | 10.1021/jm00046a009 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine