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Compound Detail

CHEMBL11359

CISPLATIN
💊 Approved Drug
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💊 Approved Drug
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ChEMBL ↗

Basic Information

ChEMBL ID CHEMBL11359
Name CISPLATIN
Phase Approved
Structure Type NONE
Therapeutic ✓ Yes

Known Names

(sp-4-2)-diamminedichloroplatinum CIS-DDP Cis-diamminedichloroplatinum Cis-diamminedichloroplatinum ii Cis-diamminedichloroplatinum(ii) Cis-platin Cis-platinum ii Cisplatin CISPLATIN COMPONENT OF INT-230-6 CISPLATIN COMPONENT OF INT230-6 Cisplatine Cisplatino +7 more
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
19
Known Names
20
Indications
1
Mechanisms

Molecular Properties

300.1
MW (Da)

Drug Information

Molecule Type Small molecule
First Approval 1978
Availability Prescription
Chirality Achiral

Routes of Administration

Parenteral

Flags

Black Box Warning
USAN Stem -platin
USAN Year 1977

Extended Properties

Molecular Formula H6Cl2N2Pt+2
MW 300.05

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
DNA inhibitor INHIBITOR DNA ✓ ✓

Indications

Neoplasms Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma of Lung Adrenal Cortex Neoplasms Anemia Anus Neoplasms Biliary Tract Neoplasms Biliary Tract Neoplasms Brain Neoplasms Brain Neoplasms Breast Neoplasms Breast Neoplasms Breast Neoplasms Carcinoma Carcinoma Carcinoma, Embryonal Carcinoma, Hepatocellular Carcinoma, Non-Small-Cell Lung

ATC Classification

L01XA01
cisplatin
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: ANTINEOPLASTIC AGENTS

Drug Warnings

Black Box Warning
nephrotoxicity
Country: United States
Black Box Warning
immune system toxicity
Country: United States
Black Box Warning
respiratory toxicity
Country: United States
Black Box Warning
hematological toxicity
Country: United States
Black Box Warning
cardiotoxicity
Country: United States
Black Box Warning
gastrointestinal toxicity
Country: United States
Black Box Warning
vascular toxicity
Country: United States

Data from ChEMBL 36 via Core Engine